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Pradaxa (dabigatran) is a blood thinner approved by the FDA in 2010. It is an oral anticoagulent used to prevent blood clots and strokes in patients with a heart condition known as atrial fibrillation. Pradaxa was marketed as a more effective and safe alternative to other blood thinners.
All blood thinners can cause spontaneous internal bleeding and dangerously excessive bleeding when there is trauma, such as a fall. However, with older blood thinners, such as warfarin, there are ways to rapidly counteract the anticlotting effects.
There is no reversal agent for Pradaxa and it is not affected by plasma factor VIIa, and factor concentrates. The only way to stop the bleeding is to get Pradaxa out of the body. This requires dialysis, but it takes several hours of dialysis and even that only gets up to 60% of the drug out of the blood.
Many doctors do not even know to try dialysis when a patient presents with Pradaxa bleeding. Even when they do, it is not always a realistic option. Even if dialysis is started right away, it may not be effective enough, fast enough, to save a patient who is bleeding to death.
The main alternative to Pradaxa is Warfarin. This has been on the market for over 50 years, but Warfarin may also cause internal bleeding among some patients. However, Warfarin may be a safer alternative for some patients because it has a known antidote that works. For those experiencing internal bleeding with Warfarin, plasma, vitamin K or prothrombin complex concentrates can be administered. Pradaxa has no antidote and emergency dialysis may be the only option and often comes too late.
There are many injuries associated with Pradaxa. Here are some common Pradaxa side effects:
Any of the following could be a symptom of internal bleeding and you should contact your doctor immediately:
If you are experiencing any of these symptoms, it is important for you to call your doctor immediately. The earlier you can catch internal bleeding, the better.
We are no longer accepting Pradaxa cases
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